Can the Genie be used with only one Genie Mini in the Tilting orientation?

Yes.

If you wish to achieve a Pan & Tilt OR Track & Tilt movement using the combination of a Genie and Genie Mini, this can indeed be achieved. However, you must firmware update the Genie to Firmware Version 2.8.4 ( Genie Firmware 2.8.4 ) and download the Genie II APP on your phone. Both the Genie Mini and the Genie could then be controllable via the Genie II APP to make this setup work.